STUDIES ON GLYCOGEN NEPHROSIS IN ALLOXAN-TREATED DIABETIC RATS
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چکیده
منابع مشابه
Studies on Glycogen Nephrosis in Alloxan-treated Diabetic Rats
Two hundred and seven albino rats were injected subcutaneously with alloxan in doses varying from 140 to 200 mg. per cent per kilo of body weight. Fifty-nine animals which developed hyperglycemia (blood sugar levels above 150 mg. per cent) were observed for periods from 5 days to 32 weeks. Postmortem examination of the kidneys of these diabetic animals revealed glycogen deposition in the loops ...
متن کاملLiver Glycogen Synthesis in Intact Alloxan Diabetic Rats.
It is now clearly established that insulin controls the utilization of glucose by muscle and adipose tissue (l-4), presumably by stimulating glucose transport across an otherwise impermeable cell membrane. Although a similar role of insulin in hepatic glucose uptake seems unlikely, since the liver cell is reported to be freely permeable to both inflow and outflow of glucose (5), there is nevert...
متن کاملA dynamic role of liver glycogen in alloxan diabetic rats.
The effect of alloxan diabetes on mobilization of the liver glycogen was followed in male rats given one injection of alloxan (200mg/kg). The serum glucose showed a typical triphasic curve, reaching sustained hyperglycemia 24hr after injection. The insulin levels of serum and pancreatic tissue extract remained within normal limits for the first 24hr. The marked decrease in insulin levels from b...
متن کاملEnzymic studies on the lenses of alloxan-diabetic rats.
The accumulation of sorbitol has been described as one of the causative factors of the diabetic cataract (Kinoshita, 1974; Dvornik et al., 1973), and hyperglycaemia seems to have a potentiating effect on the formation of the senile type of cataract. Pirie & van Heyningen (1964) found that, in the cataractous lenses of the diabetic patients, more glucose and fructose accumulated than in non-diab...
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s Liver glycogen content and liver glycogen synthesis are lowered in diabetes mellitus due to lack of functioning insulin. Many enzymes of glycogen metabolism as well as glucose metabolism are sulfhydryl in nature and are affected by changes in cellular thiol-disulfide ratio. Certain low molecular weight thiols can influence glucose uptake and utilization in fat cells and in muscle cells. A stu...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1947
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.85.4.373